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At 3 Tesla, detection of 2-HG with magnetic resonance spectroscopy is challenging because of metabolite signal overlap and a spectral pattern modulated by slice selection and chemical shift displacement. Jezzard, Peter Cadoux-Hudson, Tom Ansorge, Olaf Emir, Uzay E.Ģ-hydroxyglutarate (2-HG) has emerged as a biomarker of tumour cell IDH mutations that may enable the differential diagnosis of glioma patients. Mccullagh, James Stacey, Richard Yildirim, Muhammed Schofield, Christopher J. Improved localisation for 2-hydroxyglutarate detection at 3 T using long-TE semi-LASERīerrington, Adam Voets, Natalie L. Our results provide evidence that CR can delay immune senescence in nonhuman primates, potentially contributing to an extended lifespan by reducing susceptibility to infectious disease. Furthermore, CR also improved T cell function and reduced production of inflammatory cytokines by memory T cells. CR effected a marked improvement in the maintenance and/or production of naÃ¯ve T cells and the consequent preservation of T cell receptor repertoire diversity.

Here we show that long-term CR delays the adverse effects of aging on nonhuman primate T cells. Previous studies involving 2- to 4-year CR treatment of long-lived primates failed to find a CR effect or reported effects on the immune system opposite to those seen in CR-treated rodents. However, it is unclear whether CR can exert similar effects in long-lived organisms. In rodents, CR was reported to delay the aging of the immune system (immune senescence), which is believed to be largely responsible for a dramatic increase in age-related susceptibility to infectious diseases. Mori, Motomi Nikolich-Å½ugich, JankoĬaloric restriction (CR) has long been known to increase median and maximal lifespans and to decreases mortality and morbidity in short-lived animal models, likely by altering fundamental biological processes that regulate aging and longevity.

Messaoudi, Ilhem Warner, Jessica Fischer, Miranda Park, Buyng Hill, Brenna Mattison, Julie Lane, Mark A. All rights reserved.ĭelay of T cell senescence by caloric restriction in aged long-lived nonhuman primates This study provides evidence of persistent improvements in reading in children and adolescents with dyslexia, constituting a new rehabilitative approach for the remediation of dyslexia.

No long-term adverse effects were documented. No differences emerged in the sham group. Specifically, the non-word reading efficiency index improved at every time point, as did the low-frequency word reading efficiency index at 1 and 6 months after the end of the treatment. The active group received long-lasting benefits in reading. The long-term tolerability to tDCS was also evaluated. Reading measures (text, high- and low-frequency words, non-words) were recorded before and immediately after the treatment and 1 and 6 months later. The participants were randomly assigned to receive active or sham treatment. Twenty-six children and adolescents with dyslexia received 3 20-min sessions per week for 6 weeks (18 sessions) of left anodal/right cathodal tDCS, set to 1â€¯mA, over the parieto-temporal regions, combined with training for reading. This study confirmed the ameliorative effects of multiple sessions of transcranial direct current stimulation ( tDCS) combined with a training for reading on the reading abilities of children and adolescents with dyslexia and examined whether they are long-lasting. However, its long-term effects have not been determined. Noninvasive brain stimulation transiently modulates reading ability in individuals with dyslexia by facilitating the underactive neural pathways in them.

Long-lasting improvement following tDCS treatment combined with a training for reading in children and adolescents with dyslexia.Ĭostanzo, Floriana Rossi, Serena Varuzza, Cristiana Varvara, Pamela Vicari, Stefano Menghini, Deny

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